Long-term plasticity of hippocampal interneurons during in vivo memory processes

Formation of a cell assembly, a group of cortical neurons that function co-operatively to sustain an active memory trace, arises from changes in the connections between neurons. Establishment of memory traces is thought to rely on long-term plasticity in excitatory glutamatergic synapses interconnec...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Lamsa Karri
Lau Petrina
Dokumentumtípus: Cikk
Megjelent: 2019
Sorozat:CURRENT OPINION IN NEUROBIOLOGY 54
doi:10.1016/j.conb.2018.08.006

mtmt:3415159
Online Access:http://publicatio.bibl.u-szeged.hu/16555
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520 3 |a Formation of a cell assembly, a group of cortical neurons that function co-operatively to sustain an active memory trace, arises from changes in the connections between neurons. Establishment of memory traces is thought to rely on long-term plasticity in excitatory glutamatergic synapses interconnecting principal cells. In addition, recent studies in the hippocampus in vivo indicate that reconfiguration of GABAergic inhibitory interneuron activity also occurs during long-term memory encoding. Recent experiments in anesthetized, as well as in freely moving animals, demonstrate that learning-related hippocampal activities are associated with persistent changes in GABAergic interneuron firing rates and alterations in protein expression levels regulating GABA release. 
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