Long-term plasticity of hippocampal interneurons during in vivo memory processes
Formation of a cell assembly, a group of cortical neurons that function co-operatively to sustain an active memory trace, arises from changes in the connections between neurons. Establishment of memory traces is thought to rely on long-term plasticity in excitatory glutamatergic synapses interconnec...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2019
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| Sorozat: | CURRENT OPINION IN NEUROBIOLOGY
54 |
| doi: | 10.1016/j.conb.2018.08.006 |
| mtmt: | 3415159 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/16555 |
| Tartalmi kivonat: | Formation of a cell assembly, a group of cortical neurons that function co-operatively to sustain an active memory trace, arises from changes in the connections between neurons. Establishment of memory traces is thought to rely on long-term plasticity in excitatory glutamatergic synapses interconnecting principal cells. In addition, recent studies in the hippocampus in vivo indicate that reconfiguration of GABAergic inhibitory interneuron activity also occurs during long-term memory encoding. Recent experiments in anesthetized, as well as in freely moving animals, demonstrate that learning-related hippocampal activities are associated with persistent changes in GABAergic interneuron firing rates and alterations in protein expression levels regulating GABA release. |
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| Terjedelem/Fizikai jellemzők: | 20-27 |
| ISSN: | 0959-4388 |