Environmentally benign asymmetric Michael addition to maleimides using mechanochemical activation
The preparation of chiral N-substituted succinimides is highly important since they are widely used intermediates in the pharmaceutical industry. Such compounds can be obtained by the Michael addition of nucleofiles to different maleimides. Since the environmental awareness is rising nowadays, there...
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| Dokumentumtípus: | Könyv része |
| Megjelent: |
University of Szeged
Szeged
2023
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
29 |
| Kulcsszavak: | Analitikai kémia |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/82415 |
| LEADER | 02473naa a2200241 i 4500 | ||
|---|---|---|---|
| 001 | acta82415 | ||
| 005 | 20231123091318.0 | ||
| 008 | 231123s2023 hu o 1|| eng d | ||
| 020 | |a 978-963-306-963-9 | ||
| 040 | |a SZTE Egyetemi Kiadványok Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kőszegi Kristóf András | |
| 245 | 1 | 0 | |a Environmentally benign asymmetric Michael addition to maleimides using mechanochemical activation |h [elektronikus dokumentum] / |c Kőszegi Kristóf András |
| 260 | |a University of Szeged |b Szeged |c 2023 | ||
| 300 | |a 182-186 | ||
| 490 | 0 | |a Proceedings of the International Symposium on Analytical and Environmental Problems |v 29 | |
| 520 | 3 | |a The preparation of chiral N-substituted succinimides is highly important since they are widely used intermediates in the pharmaceutical industry. Such compounds can be obtained by the Michael addition of nucleofiles to different maleimides. Since the environmental awareness is rising nowadays, there is a huge demand for sustainable synthetic methods that can be applied industrially. Carrying out reactions using efficient alternative activation is key to achieve environmentally friendly procedures. Asymmetric catalytic processes have been developed for Michael additions on maleimides using organocatalysts under batch conditions. Our aim was to carry out the implementation of mechanochemical activation in these reactions because of its huge benefits over the conventional methods, i.e. solvent-free conditions and significantly reduced reaction times. In the present study, we examined the impact of milling parameters through the test reaction of isobutyraldehyde and N-methylmaleimide. We set the goal to achieve similar conversion and enantioselectivity values as were obtained using thermal activation but without the addition of a solvent and under much less time. As a result of our studies, optimal conditions were determined to carry out the preparation of an N-substituted succinimide, which may be a significant step in the development of sustainable industrial synthetic methods of important pharmaceutical fine chemicals. | |
| 650 | 4 | |a Természettudományok | |
| 650 | 4 | |a Kémiai tudományok | |
| 695 | |a Analitikai kémia | ||
| 700 | 0 | 1 | |a Szőllősi György |e aut |
| 711 | |a 29th International Symposium on Analytical and Environmental Problems |c Szeged |d 2023. november 13-14. | ||
| 856 | 4 | 0 | |u http://acta.bibl.u-szeged.hu/82415/1/proceedings_of_isaep_2023_182-186.pdf |z Dokumentum-elérés |