APOE epsilon status in Hungarian patients with primary progressive multiple sclerosis

PRINCIPLES: Apolipoprotein E (ApoE), an important glycoprotein in the transport, uptake and redistribution of cholesterol, is necessary in nerve tissue repair. The APOE gene (APOE) is involved in neurodegenerative diseases, the best-known association being that between the APOE epsilon4 allele and A...

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Main Authors: Losonczi Erika
Bencsik Krisztina
Fricska-Nagy Zsanett
Honti Viktor
Szalczer Estilla
Rajda Cecília
Illés Zsolt László
Mátyás Klotild
Rózsa Csilla
Csépány Tünde
Füvesi Judit
Vécsei László
Format: Article
Published: 2010
Series:SWISS MEDICAL WEEKLY 140
doi:10.4414/smw.2010.13119

mtmt:1482468
Online Access:http://publicatio.bibl.u-szeged.hu/9927
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Summary:PRINCIPLES: Apolipoprotein E (ApoE), an important glycoprotein in the transport, uptake and redistribution of cholesterol, is necessary in nerve tissue repair. The APOE gene (APOE) is involved in neurodegenerative diseases, the best-known association being that between the APOE epsilon4 allele and Alzheimer's disease. Multiple sclerosis (MS) is a chronic inflammatory neurological disease. The aim of this study was to assess (multicentre assessment) the possible influence of the APOE gene on the susceptibility of primary progressive MS (PPMS) in Hungary. METHODS: Polymerase chain reaction and restriction fragment length polymorphism were carried out on DNA isolated from 135 volunteers. RESULTS: The number of PPMS patients without the epsilon2 allele was found to be remarkably high, whilst the epsilon2 allele was overrepresented in the RRMS group. A markedly high frequency of the epsilon4 allele was found in the PPMS group and a very low frequency in the HC group. With regards to the clinical parameters, significant differences were observed between the RRMS and PPMS groups. Differences were also detected regarding the EDSS and MSSS scores when the patients were grouped by the presence or absence of the epsilon2 allele. All of the observed differences in the clinical parameters disappeared when the patients were further stratified by the type of MS. CONCLUSIONS: Our findings suggest that the presence of the epsilon2 and epsilon4 alleles may play a role in the development of the disease. However, if any type of the disease has already developed the alleles show no association with the clinical parameters.
Physical Description:Paper w13119-6 p
ISSN:1424-7860