A novel transgenic rabbit model with reduced repolarization reserve long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene /

A novel transgenic rabbit model with reduced repolarization reserve long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene /

We have created a novel transgenic LQT5 rabbit model with increased susceptibility to drug-induced arrhythmias that may represent a useful model for testing proarrhythmic potential and for investigations of the mechanisms underlying arrhythmias and sudden cardiac death due to repolarization disturba...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Major Péter
Baczkó István
Hiripi László
Odening Katja E.
Juhász Viktor
Kohajda Zsófia
Horváth András
Seprényi György
Kovács Mária
Virág László
Jost Norbert László
Prorok János
Ördög Balázs
Doleschall Zoltán
Nattel Stanley
Varró András
Bősze Zsuzsanna
Dokumentumtípus: Cikk
Megjelent: 2016
Sorozat:British journal of pharmacology 173 No. 12
doi:10.1111/bph.13500

mtmt:3052278
Online Access:http://publicatio.bibl.u-szeged.hu/9047
Leíró adatok
Tartalmi kivonat:We have created a novel transgenic LQT5 rabbit model with increased susceptibility to drug-induced arrhythmias that may represent a useful model for testing proarrhythmic potential and for investigations of the mechanisms underlying arrhythmias and sudden cardiac death due to repolarization disturbances.
Terjedelem/Fizikai jellemzők:2046-2061
ISSN:1476-5381

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