Synthesis and biological evaluation of 13α-estrone derivatives as potential antiproliferative agents
Abstract 13α-Estrone derivatives containing various substituents on C-3 and C-17 were synthesized, and evaluated by means of MTT assays for in vitro antiproliferative activity against a panel of human adherent cancer cell lines (HeLa, MCF-7, A2780 and A431). Compounds with N-benzyltriazolylmethoxy m...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2016
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| Sorozat: | STEROIDS
113 |
| doi: | 10.1016/j.steroids.2016.05.010 |
| mtmt: | 3078352 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/8289 |
| LEADER | 01479nab a2200289 i 4500 | ||
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| 024 | 7 | |a 3078352 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
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| 100 | 1 | |a Szabó Johanna | |
| 245 | 1 | 0 | |a Synthesis and biological evaluation of 13α-estrone derivatives as potential antiproliferative agents |h [elektronikus dokumentum] / |c Szabó Johanna |
| 260 | |c 2016 | ||
| 300 | |a 14-21 | ||
| 490 | 0 | |a STEROIDS |v 113 | |
| 520 | 3 | |a Abstract 13α-Estrone derivatives containing various substituents on C-3 and C-17 were synthesized, and evaluated by means of MTT assays for in vitro antiproliferative activity against a panel of human adherent cancer cell lines (HeLa, MCF-7, A2780 and A431). Compounds with N-benzyltriazolylmethoxy moieties on C-3 proved to be more potent than their 3-hydroxy or 3-ether counterparts. Some triazoles exerted substantial cytostatic effects against particular tumor cell lines, with submicromolar IC50 values. | |
| 700 | 0 | 1 | |a Pataki Zoltán |e aut |
| 700 | 0 | 1 | |a Wölfling János |e aut |
| 700 | 0 | 1 | |a Schneider Gyula |e aut |
| 700 | 0 | 1 | |a Bózsity Noémi |e aut |
| 700 | 0 | 1 | |a Minorics Renáta |e aut |
| 700 | 0 | 1 | |a Zupkó István |e aut |
| 700 | 0 | 1 | |a Mernyák Erzsébet |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/8289/1/Steroids_Szabp_13rstrone_u.pdf |z Dokumentum-elérés |