Sexual dimorphism of cardiovascular ischemia susceptibility is mediated by heme oxygenase

We investigated the gender differences in heme-oxygenase (HO) enzyme, which produces endogenous vascular protective carbon monoxide (CO). We studied (1) the activity and expression of HO enzymes in the left ventricle (LV) and aorta, (2) basal increase in basal blood pressure provoked by arginine vas...

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Bibliographic Details
Main Authors: Pósa Anikó
Kupai Krisztina
Ménesi Rudolf
Szalai Zita
Szabó Renáta
Pintér Zoltán
Pálfi György
Gyöngyösi Mariann
Magyariné Berkó Anikó
Pávó Imre
Varga Csaba
Format: Article
Published: Hindawi Publishing Corporation 2013
Series:OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2013
doi:10.1155/2013/521563

mtmt:2473505
Online Access:http://publicatio.bibl.u-szeged.hu/7590
Description
Summary:We investigated the gender differences in heme-oxygenase (HO) enzyme, which produces endogenous vascular protective carbon monoxide (CO). We studied (1) the activity and expression of HO enzymes in the left ventricle (LV) and aorta, (2) basal increase in basal blood pressure provoked by arginine vasopressine (AVP) in vivo, (3) the heart perfusion induced by AVP, (4) the ST segment depression provoked by adrenaline and 30 seconds later phentolamine, and (5) the aorta ring contraction induced by AVP in female and male Wistar rats. We found that HO activity and the expression of HO-1 and HO-2 were increased in female rat aorta and LV. We demonstrated that the basal blood pressure and administration of AVP provoked blood pressure response are increased in the males; the female myocardium was less sensitive towards angina. Both differences could be aggravated by the inhibition of HO. The aorta rings were more susceptible towards vasoconstriction by AVP in males; isolated heart perfusion decrease was higher in males. The HO inhibition aggravated the heart perfusion in both sexes. In conclusion, the increased HO activity and expression in females might play a role in the sexual dimorphism of cardiovascular ischemia susceptibility during the reproductive age. © 2013 Anikó Pósa et al.
Physical Description:Terjedelem: 11 p.-Azonosító: 521563
ISSN:1942-0900