Intra-breath respiratory mechanics of prematurity-associated lung disease phenotypes in school-aged children
Background: Intra-breath oscillometry potentially offers detailed information regarding airway function, with increasing magnitude of difference between resistance and reactance at end-expiration to end-inspiration potentially associated with obstructive airway disease, but less is known about speci...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2025
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| Sorozat: | ERJ OPEN RESEARCH
11 No. 2 |
| Tárgyszavak: | |
| doi: | 10.1183/23120541.00840-2024 |
| mtmt: | 36077247 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/36675 |
| Tartalmi kivonat: | Background: Intra-breath oscillometry potentially offers detailed information regarding airway function, with increasing magnitude of difference between resistance and reactance at end-expiration to end-inspiration potentially associated with obstructive airway disease, but less is known about specific respiratory mechanics in preterm-born children using this methodology. We investigated whether different spirometry phenotypes of prematurity-associated lung disease (PLD) have specific intra-breath oscillometry features.; Methods: 167 school-aged (7-12 years) children, 14 with prematurity-associated obstructive lung disease (POLD; forced expiratory volume in 1 s (FEV1) <lower limit of normal (LLN), FEV1/forced vital capacity (FVC) <LLN), 11 with prematurity-associated preserved ratio impaired spirometry (pPRISm; FEV1 <LLN, FEV1/FVC ≥LLN), 90 preterm controls (FEV1 ≥LLN) and 52 term controls, performed intra-breath oscillometry at baseline, following maximal cardiopulmonary exercise testing and following post-exercise bronchodilation.; Results: Children with POLD showed greater resistance and more negative reactance throughout the respiratory cycle, including at zero-flow states of end-expiration and end-inspiration. The difference between end-expiration and end-inspiration did not show differences between groups until corrected for tidal volume, whereby children with POLD and pPRISm both demonstrated approximately two-fold greater difference compared to both preterm and term controls for resistance (2.24 and 2.22 versus 1.28 and 1.11 hPa·s·L-1, respectively), and in particular a greater magnitude of difference for reactance for children with POLD versus preterm and term controls only (-1.58 versus -0.26 and 0.03 hPa·s·L-1, respectively).; Conclusions: Intra-breath respiratory mechanics for preterm-born children with an obstructive lung phenotype have greater impedance throughout the respiratory cycle, features different to those observed in children with other wheeze phenotypes including preschool wheeze and asthma. Copyright ©The authors 2025. |
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| Terjedelem/Fizikai jellemzők: | 13 |
| ISSN: | 2312-0541 |