Human Pancreas‐Derived Organoids with Controlled Polarity Detailed Protocols and Experimental Timeline /
Since their discovery, 3D cell cultures have emerged as powerful tools across various basic, translational research, and industrial discovery projects. One such application is in the physiological and pathophysiological modeling of pancreatic exocrine functions, which addresses critical clinical cha...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2024
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| Sorozat: | CURRENT PROTOCOLS
4 No. 11 |
| Tárgyszavak: | |
| doi: | 10.1002/cpz1.70045 |
| mtmt: | 35609714 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/35517 |
| Tartalmi kivonat: | Since their discovery, 3D cell cultures have emerged as powerful tools across various basic, translational research, and industrial discovery projects. One such application is in the physiological and pathophysiological modeling of pancreatic exocrine functions, which addresses critical clinical challenges, including acute and chronic pancreatitis. While several methods now exist for generating epithelial organoids (derived from induced pluripotent, embryonic, or adult stem cells), the advent of patient‐derived organoids (PDOs) with controlled polarity has introduced a new frontier in pancreatic research. This advancement has significantly expanded the methodological arsenal available for studying human pancreatic epithelial secretion. |
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| Terjedelem/Fizikai jellemzők: | 25 |
| ISSN: | 2691-1299 |