Different PSMA Radiopharmaceuticals A Comparative Study of [18F]F-PSMA-1007, [18F]F-JK-PSMA-7, and [99mTc]Tc-PSMA-I&S in the Skeletal System /

Different PSMA Radiopharmaceuticals A Comparative Study of [18F]F-PSMA-1007, [18F]F-JK-PSMA-7, and [99mTc]Tc-PSMA-I&S in the Skeletal System /

Background: Numerous PSMA-based tracers are used for diagnostic prostate cancer imaging, but comprehensive comparisons between multiple ligands are lacking. This study aimed to compare physiological skeletal uptake and tracer uptake in commonly recommended PSMA reference regions across three differe...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Mikó Zsófia Sára
Varga László
Farkas István
Tóth Gyula
Apró Kristóf
Révész Barnabás Márk
Sipka Gábor
Tompa Péter Gergő
Bakos Annamária
Czékus Tamás
Bukva Mátyás
Pávics László
Varga Linda
Maráz Anikó
Besenyi Zsuzsanna
Dokumentumtípus: Cikk
Megjelent: 2024
Sorozat:PHARMACEUTICALS 17 No. 11
Tárgyszavak:
Klinikai orvostan
doi:10.3390/ph17111458

mtmt:35498039
Online Access:http://publicatio.bibl.u-szeged.hu/35359
Leíró adatok
Tartalmi kivonat:Background: Numerous PSMA-based tracers are used for diagnostic prostate cancer imaging, but comprehensive comparisons between multiple ligands are lacking. This study aimed to compare physiological skeletal uptake and tracer uptake in commonly recommended PSMA reference regions across three different PSMA ligands in prostate cancer patients. Methods: A total of 281 prostate cancer patients were included. Using PET and SPECT imaging, target volumes of interest were defined via a semiautomatic method, and standardized uptake values (SUV) were calculated for the skeletal system and reference regions (liver, spleen, parotid gland, and blood pool). Results: Significant differences in SUV uptake were observed, with [18F]F-PSMA-1007 showing higher SUV values in the skeletal system. The parotid gland displayed the highest variability in uptake, while the blood pool and liver exhibited more homogeneous uptake across patients. Conclusions: While radioligands behave similarly in bone regions, there are notable differences in SUV patterns, particularly for PSMA-1007, which showed higher bone uptake. Parotid gland uptake variability suggests a reconsideration of its suitability as a reference region, while the liver, spleen, and blood pool showed more consistent uptake. During comparison, the technetium-labeled SPECT ligand proved as similarly effective as the two PET ligands for diagnostic imaging.
Terjedelem/Fizikai jellemzők:15
ISSN:1424-8247

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