The Protein Encoded by The Gene Proliferation Disrupter (prod) is Associated With The Telomeric Retrotransposon Array in Drosophila Melanogaster
We report in this paper that the pentoxyresorufin-O-dealkylase (PROD) protein, encoded by the gene proliferation disrupter (prod), is associated with the telomeric chromatin in Drosophila melanogaster. It binds to a region just upstream of the promoter of the telomere-specific retrotransposon HeT-A,...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2007
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| Sorozat: | CHROMOSOMA
116 No. 2 |
| Tárgyszavak: | |
| doi: | 10.1007/s00412-006-0090-4 |
| mtmt: | 1915168 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/34310 |
| Tartalmi kivonat: | We report in this paper that the pentoxyresorufin-O-dealkylase (PROD) protein, encoded by the gene proliferation disrupter (prod), is associated with the telomeric chromatin in Drosophila melanogaster. It binds to a region just upstream of the promoter of the telomere-specific retrotransposon HeT-A, which is located in the long 3'untranslated region of the element near its oligo(A) tail. Reduction of PROD in prod heterozygote flies results in elevated levels of HeT-A RNA in the ovaries, suggesting that PROD functions as a repressor of HeT-A transcriptional activity at the telomeres. |
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| Terjedelem/Fizikai jellemzők: | 185-195 |
| ISSN: | 0009-5915 |