Increasing the solubility characteristics of iomeglamic acid with β-cyclodextrin
Iomeglamic acid has been successfully applied for radioscopy of the gall-bladder since 1972. This pharmacon has the disadvantageous property that it is practically insoluble in water. Preparations containing the drug in different concentrations were made with β-cyclodextrin by different methods, and...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1989
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| Sorozat: | JOURNAL OF INCLUSION PHENOMENA
7 No. 3 |
| Tárgyszavak: | |
| doi: | 10.1007/BF01076981 |
| mtmt: | 1912749 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32750 |
| Tartalmi kivonat: | Iomeglamic acid has been successfully applied for radioscopy of the gall-bladder since 1972. This pharmacon has the disadvantageous property that it is practically insoluble in water. Preparations containing the drug in different concentrations were made with β-cyclodextrin by different methods, and their dissolution characteristics were determined. In the best situation the solubility increased ten-fold. The tablets were made from the most suitable complex, with β-cyclodextrin. The conditions of tableting, the parameters and the dissolution of the tablets were tested. © 1989 Kluwer Academic Publishers. |
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| Terjedelem/Fizikai jellemzők: | 289-299 |
| ISSN: | 0167-7861; 2214-7225 |