Klorokinium-foszfát tartalmú végbélkúpok gyártástechnológiája és in vitro vizsgálata [Production technology and in vitro study of rectal suppositories containing chloroquine-phosphate]
Chloroquine-phosphate was suspended in various lipophilic and hydrophilic suppository bases in an amount of 250 mg/2.0 g. The authors studied the solidity and the disintegration time of the suppositories as well as the in vitro drug liberation with a membrane diffusion method. The effect of the stor...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1995
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| Sorozat: | ACTA PHARMACEUTICA HUNGARICA
65 No. 2 |
| Tárgyszavak: | |
| mtmt: | 1767251 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32530 |
| Tartalmi kivonat: | Chloroquine-phosphate was suspended in various lipophilic and hydrophilic suppository bases in an amount of 250 mg/2.0 g. The authors studied the solidity and the disintegration time of the suppositories as well as the in vitro drug liberation with a membrane diffusion method. The effect of the storage time and the storage circumstances on the stability of the suppositories was observed. Tropics-resistance studies were also carried out at a temperature of 45°C and at a relative humidity content of 75%, thus these suppositories may be used for the treatment of malaria. The Witepsol H 15 base was found to be the best in all respect for use in counties with a continental climate. Finally a function relationship was found between the concentration of the pharmacon and the diffusion time with linear regression analysis. |
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| Terjedelem/Fizikai jellemzők: | 45-50 |
| ISSN: | 0001-6659 |