Effect of benzo[a]phenothiazines on natural killer cell activity of human peripheral blood mononuclear cells
Four benzo[a]phenothiazines were investigated for their effects on antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) cell and blast transformation of human peripheral blood mononuclear cells (PBM). Benzo[a]phenothiazines dose-dependently suppressed the mitogen-stimulated T cell...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1993
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| Sorozat: | ANTICANCER RESEARCH
13 No. 6 A |
| Tárgyszavak: | |
| mtmt: | 1918217 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32159 |
| Tartalmi kivonat: | Four benzo[a]phenothiazines were investigated for their effects on antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) cell and blast transformation of human peripheral blood mononuclear cells (PBM). Benzo[a]phenothiazines dose-dependently suppressed the mitogen-stimulated T cell proliferation. The suppressive effect of non differentiation-inducing benzo[a]phenothiazines was higher than that of differentiation-inducing benzo[a]phenothiazines. The stimulation effect of differentiation-inducing compounds on the NK activity was reduced by removal of monocytes from the PBM. The results suggest the direct activation of monocytes (Mo) by differentiation-inducing benzo[a]phenothiazines. |
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| Terjedelem/Fizikai jellemzők: | 2273-2275 |
| ISSN: | 0250-7005 |