Paracetamol-tartalmú kúpok in vitro és in vivo vizsgálata [In vitro and in vivo study of acetaminophen-containing suppositories]
Rectal suppositories with a paracetamol content of 300 mg were prepared and the optimal vehicle was searched for experimentally. 9 different kinds of lipophilic, lipohydrophilic and hydrophilic vehicles were used for this purpose. Research was focused on determining the factors influencing in vitro...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1994
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| Sorozat: | ACTA PHARMACEUTICA HUNGARICA
64 No. 2 |
| Tárgyszavak: | |
| mtmt: | 1767253 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32069 |
| Tartalmi kivonat: | Rectal suppositories with a paracetamol content of 300 mg were prepared and the optimal vehicle was searched for experimentally. 9 different kinds of lipophilic, lipohydrophilic and hydrophilic vehicles were used for this purpose. Research was focused on determining the factors influencing in vitro drug liberation. The suppository compositions which proved to be the best by the membrane diffusion method were tested by in vivo animal experiments with respect to their antipyretic effect. The in vitro and in vivo results were evaluated statistically and some of the suppository bases showed significant differences. In the authors' opinion the optimal vehicle for the preparation of paracetamol-containing suppositories is the Witepsol H 15 suppository base containing 10% Miglyol 812 (neutral oil). |
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| Terjedelem/Fizikai jellemzők: | 45-49 |
| ISSN: | 0001-6659 |