Saturated heterocycles. Part 209. Synthesis of 1‐cyclohexyl‐substituted isoquinoline derivatives
In contrast with earlier literature data [7], both acrylic esters and acrylonitrile underwent Michael addition to 1-methyl-3,4-dihydroisoquinolines 14 to yield the diesters 5-9 or the dinitrile 10, respectively. Compounds S-10 were converted by Claisen condensation to 1-[(3'-methoxycarbonyl- or...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1994
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| Sorozat: | JOURNAL OF HETEROCYCLIC CHEMISTRY
31 No. 4 |
| Tárgyszavak: | |
| doi: | 10.1002/jhet.5570310423 |
| mtmt: | 28001 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/31967 |
| Tartalmi kivonat: | In contrast with earlier literature data [7], both acrylic esters and acrylonitrile underwent Michael addition to 1-methyl-3,4-dihydroisoquinolines 14 to yield the diesters 5-9 or the dinitrile 10, respectively. Compounds S-10 were converted by Claisen condensation to 1-[(3'-methoxycarbonyl- or 1-[(3'-ethoxycarbonyl-4'-oxo)-1-cyclohexyl]-3,4-dihydroisoquinoline derivatives 11-16. Several derivatives of 12 were prepared. The new compounds possess various pharmacological actions. |
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| Terjedelem/Fizikai jellemzők: | 825-828 |
| ISSN: | 0022-152X |