Effects of inorganic and organic mercury on cortical and hippocampal activity in rats
People are exposed to inorganic or organic mercury in various occupational and environmental settings. The aim of this study was to see the effect of an inorganic and an organic mercury compound on spontaneous and stimulus-evoked central nervous activity in rats under identical experimental conditio...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2002
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| Sorozat: | CENTRAL EUROPEAN JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
8 No. 2-3 |
| Tárgyszavak: | |
| mtmt: | 1294357 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/27657 |
| Tartalmi kivonat: | People are exposed to inorganic or organic mercury in various occupational and environmental settings. The aim of this study was to see the effect of an inorganic and an organic mercury compound on spontaneous and stimulus-evoked central nervous activity in rats under identical experimental conditions. Male Wistar rats were treated for 10 weeks with 0.5 and 2.0 mg/kg b.w. of mercuric chloride (HgCl2) or methylmercury chloride (CH3HgCl) per os by gavage. For neurophysiological investigation, the animals were anaesthetized, placed in a stereotaxic instrument, and the left hemisphere was exposed. Activity was recorded from the primary somatosensory, visual and auditory fields, and the hippocampal CA1 region. There was no qualitative difference between the effects of inorganic and organic mercury but the same dose of methylmercury generally elicited more marked alterations. In the spontaneous cortical and hippocampal activity, the peak of activity was shifted to higher frequencies. The duration of the somatosensory and visual cortical evoked potentials were significantly shortened by organic but hardly affected by inorganic mercury. Methylmercury had a stronger effect on the tetanic potentiation of hippocampal evoked activity (population spike) than mercury chloride had.. Our results indicate that differences in chemical character and neurotoxicity are only partially in line. |
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| Terjedelem/Fizikai jellemzők: | 118-125 |
| ISSN: | 1219-1221 |