Neurotoxic Effects of Metal Oxide Nanoparticles on the Somatosensory System of Rats Following Subacute Intratracheal Application
Metal-containing nanoparticles have newly been recognized as one of the major factors in occupational and other inhalation exposures. Fumes containing manganese, cadmium or lead are formed in high-temperature industrial processes. Metal oxide (MnO2, CdO2, PbO) nano¬particles were synthesized and ins...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2008
|
| Sorozat: | CENTRAL EUROPEAN JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
14 No. 3 |
| Tárgyszavak: | |
| mtmt: | 1294684 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/27634 |
| Tartalmi kivonat: | Metal-containing nanoparticles have newly been recognized as one of the major factors in occupational and other inhalation exposures. Fumes containing manganese, cadmium or lead are formed in high-temperature industrial processes. Metal oxide (MnO2, CdO2, PbO) nano¬particles were synthesized and instilled in aqueous suspension in the trachea of rats for 6 weeks, and functional changes in the somatosensory system were studied. From treated rats, as well as untreated and vehicle controls, spontaneous and stimulus-evoked activity of the primary somatosensory cortex, and compound action potential from the tail nerve, were recorded in urethane anaesthesia. In the spontaneous activity there was a shift to higher frequencies in all treated groups. The latency of the somatosensory evoked potential was typically lengthened and its dependence on the frequency of stimulation increased by high dose of Cd and Pb, and by high and low dose of Mn. On the tail nerve, Pb had the strongest effect. The similarity of the three metals’ effects indicated common mechanisms of action, most likely disturbance of Ca-dependent neuronal phenomena and oxidative stress. |
|---|---|
| Terjedelem/Fizikai jellemzők: | 277-290 |
| ISSN: | 1219-1221 |