Alterations in the action potential of Aplysia neurons evoked by a phorbolester are mediated by protein kinase C
Alterations in the parameters of action potentials upon changes in protein kinase C (PKC) activity were studied on neurons of the visceral ganglion of Aplysia californica. The amplitude and maximum speed of the up-and downstroke of the action potentials (APs) were measured. Intracellularly injected...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
1995
|
| Sorozat: | BRAIN RESEARCH
684 No. 1 |
| Tárgyszavak: | |
| doi: | 10.1016/0006-8993(95)00437-U |
| mtmt: | 1240485 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/27600 |
| Tartalmi kivonat: | Alterations in the parameters of action potentials upon changes in protein kinase C (PKC) activity were studied on neurons of the visceral ganglion of Aplysia californica. The amplitude and maximum speed of the up-and downstroke of the action potentials (APs) were measured. Intracellularly injected PKC and intra-and extracellularly applied phorbol-12,13-diacetate (PDAc) had similar effects on the Aplysia neurons, the most prominent being an increase of the upstroke speed of the AP in every neuron. The non-PKC-activating 4Îą-phorbol didecanoate had no effect, and the effects of the PKC blocker H-7 were opposite to those of PDAc. It was concluded that the changes of the AP evoked by PDAc are mediated through PKC activation. |
|---|---|
| Terjedelem/Fizikai jellemzők: | 107-111 |
| ISSN: | 0006-8993 |