correctKin an optimized method to infer relatedness up to the 4th degree from low-coverage ancient human genomes /
Kinship analysis from very low-coverage ancient sequences has been possible up to the second degree with large uncertainties. We propose a new, accurate, and fast method, correctKin, to estimate the kinship coefficient and the confidence interval using low-coverage ancient data. We perform simulatio...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2023
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| Sorozat: | GENOME BIOLOGY
24 No. 1 |
| Tárgyszavak: | |
| doi: | 10.1186/s13059-023-02882-4 |
| mtmt: | 33677647 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/26675 |
| Tartalmi kivonat: | Kinship analysis from very low-coverage ancient sequences has been possible up to the second degree with large uncertainties. We propose a new, accurate, and fast method, correctKin, to estimate the kinship coefficient and the confidence interval using low-coverage ancient data. We perform simulations and also validate correctKin on experimental modern and ancient data with widely different genome coverages (0.12×–11.9×) using samples with known family relations and known/unknown population structure. Based on our results, correctKin allows for the reliable identification of relatedness up to the 4th degree from variable/low-coverage ancient or badly degraded forensic whole genome sequencing data. |
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| Terjedelem/Fizikai jellemzők: | 21 |
| ISSN: | 1474-7596 |