Estradiol-Based Salicylaldehyde (Thio)semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities
A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1H and ¹³C nuclear magnetic resonance spectroscopy, UV–visible and electron paramagnetic resonance spectrosc...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2023
|
| Sorozat: | MOLECULES
28 No. 1 |
| Tárgyszavak: | |
| doi: | 10.3390/molecules28010054 |
| mtmt: | 33416616 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/25875 |
| LEADER | 02570nab a2200349 i 4500 | ||
|---|---|---|---|
| 001 | publ25875 | ||
| 005 | 20221227110706.0 | ||
| 008 | 221227s2023 hu o 0|| Angol d | ||
| 022 | |a 1420-3049 | ||
| 024 | 7 | |a 10.3390/molecules28010054 |2 doi | |
| 024 | 7 | |a 33416616 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a Angol | ||
| 100 | 1 | |a Petrasheuskaya Tatsiana | |
| 245 | 1 | 0 | |a Estradiol-Based Salicylaldehyde (Thio)semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities |h [elektronikus dokumentum] / |c Petrasheuskaya Tatsiana |
| 260 | |c 2023 | ||
| 300 | |a 26 | ||
| 490 | 0 | |a MOLECULES |v 28 No. 1 | |
| 520 | 3 | |a A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1H and ¹³C nuclear magnetic resonance spectroscopy, UV–visible and electron paramagnetic resonance spectroscopy, electrospray ionization mass spectrometry and elemental analysis. The structure of the Cu(II)-estradiol-semicarbazone complex was revealed by X-ray crystallography. Proton dissociation constants of the ligands and stability constants of the metal complexes were determined in 30% (v/v) DMSO/H2O. Estradiol-(T)SCs form mono-ligand complexes with Cu(II) ions and exhibit high stability with the exception of estradiol-SC. The Cu(II) complexes of estradiol-TSC and its N,N-dimethyl derivative displayed the highest cytotoxicity among the tested compounds in MCF-7, MCF-7 KCR, DU-145, and A549 cancer cells. The complexes do not damage DNA according to both in vitro cell-free and cellular assays. All the Cu(II)-TSC complexes revealed significant activity against the Gram-positive Staphylococcus aureus bacteria strain. Estradiol-TSCs showed efficient antioxidant activity, which was decreased by complexation with Cu(II) ions. The exchange of estrone moiety to estradiol did not result in significant changes to physico-chemical and biological properties. | |
| 650 | 4 | |a Kémiai tudományok | |
| 700 | 0 | 1 | |a Kovács Ferenc |e aut |
| 700 | 0 | 1 | |a Igaz Nóra |e aut |
| 700 | 0 | 1 | |a Rónavári Andrea |e aut |
| 700 | 0 | 1 | |a Hajdu Bálint |e aut |
| 700 | 0 | 2 | |a Nagyné Bereczki Laura |e aut |
| 700 | 0 | 2 | |a May Nóra Veronika |e aut |
| 700 | 0 | 2 | |a Spengler Gabriella |e aut |
| 700 | 0 | 2 | |a Gyurcsik Béla |e aut |
| 700 | 0 | 2 | |a Csontné Kiricsi Mónika |e aut |
| 700 | 0 | 2 | |a Nagyné Frank Éva |e aut |
| 700 | 0 | 2 | |a Enyedy Éva Anna |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/25875/7/33416616.pdf |z Dokumentum-elérés |