Quality by Design-Driven Zeta Potential Optimisation Study of Liposomes with Charge Imparting Membrane Additives
Liposomal formulations, as versatile nanocarrier systems suitable for targeted delivery, have a highly focused role in the therapy development of unmet clinical needs and diagnostic imaging techniques. Formulating nanomedicine with suitable zeta potential is an essential but challenging task. Formul...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2022
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| Sorozat: | PHARMACEUTICS
14 No. 9 |
| Tárgyszavak: | |
| doi: | 10.3390/pharmaceutics14091798 |
| mtmt: | 33070907 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/25002 |
| LEADER | 02727nab a2200301 i 4500 | ||
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| 001 | publ25002 | ||
| 005 | 20220902141247.0 | ||
| 008 | 220902s2022 hu o 0|| Angol d | ||
| 022 | |a 1999-4923 | ||
| 024 | 7 | |a 10.3390/pharmaceutics14091798 |2 doi | |
| 024 | 7 | |a 33070907 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a Angol | ||
| 100 | 1 | |a Németh Zsófia | |
| 245 | 1 | 0 | |a Quality by Design-Driven Zeta Potential Optimisation Study of Liposomes with Charge Imparting Membrane Additives |h [elektronikus dokumentum] / |c Németh Zsófia |
| 260 | |c 2022 | ||
| 300 | |a Terjedelem: 25 p.-Azonosító: 1798 | ||
| 490 | 0 | |a PHARMACEUTICS |v 14 No. 9 | |
| 520 | 3 | |a Liposomal formulations, as versatile nanocarrier systems suitable for targeted delivery, have a highly focused role in the therapy development of unmet clinical needs and diagnostic imaging techniques. Formulating nanomedicine with suitable zeta potential is an essential but challenging task. Formulations with a minimum ±30 mV zeta potential are considered stable. The charge of the phospholipid bilayer can be adjusted with membrane additives. The present Quality by Design-derived study aimed to optimise liposomal formulations prepared via the thin-film hydration technique by applying stearylamine (SA) or dicetyl phosphate (DCP) as charge imparting agents. This 32 fractional factorial design-based study determined phosphatidylcholine, cholesterol, and SA/DCP molar ratios for liposomes with characteristics meeting the formulation requirements. The polynomials describing the effects on the zeta potential were calculated. The optimal molar ratios of the lipids were given as 12.0:5.0:5.0 for the SA-PBS pH 5.6 (optimised sample containing stearylamine) and 8.5:4.5:6.5 for the DCP-PBS pH 5.6 (optimised sample containing dicetyl phosphate) particles hydrated with phosphate-buffered saline pH 5.6. The SA-PBS pH 5.6 liposomes had a vesicle size of 108 ± 15 nm, 0.20 ± 0.04 polydispersity index, and +30.1 ± 1.2 mV zeta potential, while these values were given as 88 ± 14 nm, 0.21 ± 0.02, and −36.7 ± 3.3 mV for the DCP-PBS pH 5.6 vesicles. The prepared liposomes acquired the requirements of the zeta potential for stable formulations. | |
| 650 | 4 | |a Farmakológia és gyógyszerészet | |
| 700 | 0 | 2 | |a Pannonhalminé Csóka Ildikó |e aut |
| 700 | 0 | 2 | |a Semnani Jazani Reza |e aut |
| 700 | 0 | 2 | |a Sipos Bence |e aut |
| 700 | 0 | 2 | |a Haspel Henrik |e aut |
| 700 | 0 | 2 | |a Kozma Gábor |e aut |
| 700 | 0 | 2 | |a Kónya Zoltán |e aut |
| 700 | 0 | 2 | |a Dobó Dorina Gabriella |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/25002/1/2022_Nemeth_QualitybyDesign-drivenzetapotentialoptimisationstudyofliposomeswithchargeimpartingmembraneadditives.pdf |z Dokumentum-elérés |