Autológ haemopoeticus őssejt-transzplantáció szerepe T-sejtes lymphomában Magyar adatok

T-cell lymphoma is a poor prognostic hematological malignancy. The generally used - not sufficiently effective - induction chemotherapy should be improved with consolidative autologous hemopoetic stem cell transplantation. The authors describe the role, place and effectiveness of transplantation in...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Szomor Árpád
Csalódi Renáta
Kosztolányi Szabolcs
Nagy Ágnes
Pammer Judit
Tóth Orsolya
Losonczy Hajna
Alizadeh Hussain
Mitényi Zsófia
Reményi Péter
Piukovics Klára
Dokumentumtípus: Cikk
Megjelent: 2017
Sorozat:ORVOSI HETILAP 158 No. 41
Tárgyszavak:
doi:10.1556/650.2017.30869

mtmt:3280062
Online Access:http://publicatio.bibl.u-szeged.hu/24073
Leíró adatok
Tartalmi kivonat:T-cell lymphoma is a poor prognostic hematological malignancy. The generally used - not sufficiently effective - induction chemotherapy should be improved with consolidative autologous hemopoetic stem cell transplantation. The authors describe the role, place and effectiveness of transplantation in this disorder. One hundred thirty three autologous stem cell transplantations were performed in the last 22 years in Hungary. Detailed results are available from the last 6 years. In this period 43 transplantations were carried out in 4 Hungarian centers. Carmustine-etoposide-cytosine arabinoside-melphalan (BEAM) conditioning regimen was used in 95%. The transplantation was done mainly in complete remission (84%), 1 year after transplantation 65% of patients were still in complete remission. Eleven patients died, 82% of them have progressive disease. Brentuximab vedotin has already proved the effectiveness, several other chemoterapeutics, monoclonal antibodies, kinase inhibitors are under investigation. In certain cases allogeneic stem cell transplantation has real indication among therapeutic options. Orv Hetil. 2017; 158(41): 1615-1619.
Terjedelem/Fizikai jellemzők:1615-1619
ISSN:0030-6002