Bismuth Subnitrate-Catalyzed Markovnikov-Type Alkyne Hydrations under Batch and Continuous Flow Conditions
Bismuth subnitrate is reported herein as a simple and efficient catalyst for the atom-economical synthesis of methyl ketones via Markovnikov-type alkyne hydration. Besides an effective batch process under reasonably mild conditions, a chemically intensified continuous flow protocol was also develope...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2021
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| Sorozat: | MOLECULES
26 No. 10 |
| Tárgyszavak: | |
| doi: | 10.3390/molecules26102864 |
| mtmt: | 32242848 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/23030 |
| LEADER | 01693nab a2200241 i 4500 | ||
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| 005 | 20211208083649.0 | ||
| 008 | 211208s2021 hu o 0|| Angol d | ||
| 022 | |a 1420-3049 | ||
| 024 | 7 | |a 10.3390/molecules26102864 |2 doi | |
| 024 | 7 | |a 32242848 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a Angol | ||
| 100 | 1 | |a Szécsényi Zsanett | |
| 245 | 1 | 0 | |a Bismuth Subnitrate-Catalyzed Markovnikov-Type Alkyne Hydrations under Batch and Continuous Flow Conditions |h [elektronikus dokumentum] / |c Szécsényi Zsanett |
| 260 | |c 2021 | ||
| 300 | |a Terjedelem: 12-Azonosító: 2864 | ||
| 490 | 0 | |a MOLECULES |v 26 No. 10 | |
| 520 | 3 | |a Bismuth subnitrate is reported herein as a simple and efficient catalyst for the atom-economical synthesis of methyl ketones via Markovnikov-type alkyne hydration. Besides an effective batch process under reasonably mild conditions, a chemically intensified continuous flow protocol was also developed in a packed-bed system. The applicability of the methodologies was demonstrated through hydration of a diverse set of terminal acetylenes. By simply switching the reaction medium from methanol to methanol-d(4), valuable trideuteromethyl ketones were also prepared. Due to the ready availability and nontoxicity of the heterogeneous catalyst, which eliminated the need for any special additives and/or harmful reagents, the presented processes display significant advances in terms of practicality and sustainability. | |
| 650 | 4 | |a Kémiai tudományok | |
| 700 | 0 | 1 | |a Fülöp Ferenc |e aut |
| 700 | 0 | 1 | |a Ötvös Sándor Balázs |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/23030/1/Molecules_Szecsenyi_2021_2864.pdf |z Dokumentum-elérés |