Direct writing of optical microresonators in a lab-on-a-chip for label-free biosensing
Whispering gallery mode (WGM) resonators are promising optical structures for microfluidic label-free bio-sensors mainly due to their high sensitivity, but from a practical point of view they present numerous constraints that make their use in real laboratory diagnosis application difficult. Herein...
Elmentve itt :
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Dokumentumtípus: | Cikk |
Megjelent: |
2019
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Sorozat: | LAB ON A CHIP
19 No. 11 |
Tárgyszavak: | |
doi: | 10.1039/c9lc00174c |
mtmt: | 30735098 |
Online Access: | http://publicatio.bibl.u-szeged.hu/22829 |
LEADER | 01770nab a2200289 i 4500 | ||
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001 | publ22829 | ||
005 | 20221027091650.0 | ||
008 | 211108s2019 hu o 0|| Angol d | ||
022 | |a 1473-0197 | ||
024 | 7 | |a 10.1039/c9lc00174c |2 doi | |
024 | 7 | |a 30735098 |2 mtmt | |
040 | |a SZTE Publicatio Repozitórium |b hun | ||
041 | |a Angol | ||
100 | 1 | |a Kelemen Lóránd | |
245 | 1 | 0 | |a Direct writing of optical microresonators in a lab-on-a-chip for label-free biosensing |h [elektronikus dokumentum] / |c Kelemen Lóránd |
260 | |c 2019 | ||
300 | |a 1985-1990 | ||
490 | 0 | |a LAB ON A CHIP |v 19 No. 11 | |
520 | 3 | |a Whispering gallery mode (WGM) resonators are promising optical structures for microfluidic label-free bio-sensors mainly due to their high sensitivity, but from a practical point of view they present numerous constraints that make their use in real laboratory diagnosis application difficult. Herein we report on a monolithic lab on a chip fabricated by a hybrid femtosecond laser micromachining approach, for label-free biosensing. It consists of a polymer WGM microresonator sensor integrated inside a glass microfluidic chip, presenting a refractive index change sensitivity of 61 nm per RIU. The biosensing capabilities of the device have been demonstrated by exploiting the biotin-streptavidin binding affinity, obtaining a measurable minimum surface density increase of 67 x 10(3) molecules per mu m(2). | |
650 | 4 | |a Biológiai tudományok | |
650 | 4 | |a Orvostechnikai műszaki tudományok | |
700 | 0 | 1 | |a Lepera E. |e aut |
700 | 0 | 1 | |a Horváth Bence |e aut |
700 | 0 | 1 | |a Ormos Pál |e aut |
700 | 0 | 1 | |a Osellame R. |e aut |
700 | 0 | 1 | |a Vázquez R. Martínez |e aut |
856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/22829/1/Cikk_Lab_on_a_Chip.pdf |z Dokumentum-elérés |