Direct writing of optical microresonators in a lab-on-a-chip for label-free biosensing

Whispering gallery mode (WGM) resonators are promising optical structures for microfluidic label-free bio-sensors mainly due to their high sensitivity, but from a practical point of view they present numerous constraints that make their use in real laboratory diagnosis application difficult. Herein...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Kelemen Lóránd
Lepera E.
Horváth Bence
Ormos Pál
Osellame R.
Vázquez R. Martínez
Dokumentumtípus: Cikk
Megjelent: 2019
Sorozat:LAB ON A CHIP 19 No. 11
Tárgyszavak:
doi:10.1039/c9lc00174c

mtmt:30735098
Online Access:http://publicatio.bibl.u-szeged.hu/22829
Leíró adatok
Tartalmi kivonat:Whispering gallery mode (WGM) resonators are promising optical structures for microfluidic label-free bio-sensors mainly due to their high sensitivity, but from a practical point of view they present numerous constraints that make their use in real laboratory diagnosis application difficult. Herein we report on a monolithic lab on a chip fabricated by a hybrid femtosecond laser micromachining approach, for label-free biosensing. It consists of a polymer WGM microresonator sensor integrated inside a glass microfluidic chip, presenting a refractive index change sensitivity of 61 nm per RIU. The biosensing capabilities of the device have been demonstrated by exploiting the biotin-streptavidin binding affinity, obtaining a measurable minimum surface density increase of 67 x 10(3) molecules per mu m(2).
Terjedelem/Fizikai jellemzők:1985-1990
ISSN:1473-0197