Direct writing of optical microresonators in a lab-on-a-chip for label-free biosensing
Whispering gallery mode (WGM) resonators are promising optical structures for microfluidic label-free bio-sensors mainly due to their high sensitivity, but from a practical point of view they present numerous constraints that make their use in real laboratory diagnosis application difficult. Herein...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2019
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| Sorozat: | LAB ON A CHIP
19 No. 11 |
| Tárgyszavak: | |
| doi: | 10.1039/c9lc00174c |
| mtmt: | 30735098 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/22829 |
| Tartalmi kivonat: | Whispering gallery mode (WGM) resonators are promising optical structures for microfluidic label-free bio-sensors mainly due to their high sensitivity, but from a practical point of view they present numerous constraints that make their use in real laboratory diagnosis application difficult. Herein we report on a monolithic lab on a chip fabricated by a hybrid femtosecond laser micromachining approach, for label-free biosensing. It consists of a polymer WGM microresonator sensor integrated inside a glass microfluidic chip, presenting a refractive index change sensitivity of 61 nm per RIU. The biosensing capabilities of the device have been demonstrated by exploiting the biotin-streptavidin binding affinity, obtaining a measurable minimum surface density increase of 67 x 10(3) molecules per mu m(2). |
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| Terjedelem/Fizikai jellemzők: | 1985-1990 |
| ISSN: | 1473-0197 |