Microwave-assisted, solvent-free synthesis of 1-(alpha- or beta-hydroxynaphthyl)-1,2,3,4-tetrahydroisoquinolines by the Mannich reaction

As a new extension of the Mannich reaction of naphthols, 1-(hydroxynaphthyl)-substituted 1,2,3,4-tetrahydroisoquinolines were synthesized by the nucleophilic addition of 1- or 2-naphthol to 3,4-dihydroisoquinolines under solvent-free conditions, using microwave irradiation. The additions to 3-methyl...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Szatmári István
Lázár László
Fülöp Ferenc
Dokumentumtípus: Cikk
Megjelent: 2006
Sorozat:TETRAHEDRON LETTERS 47 No. 23
Tárgyszavak:
doi:10.1016/j.tetlet.2006.03.169

mtmt:1012929
Online Access:http://publicatio.bibl.u-szeged.hu/22669
Leíró adatok
Tartalmi kivonat:As a new extension of the Mannich reaction of naphthols, 1-(hydroxynaphthyl)-substituted 1,2,3,4-tetrahydroisoquinolines were synthesized by the nucleophilic addition of 1- or 2-naphthol to 3,4-dihydroisoquinolines under solvent-free conditions, using microwave irradiation. The additions to 3-methyl-6,7-dimethoxy-3,4-dihydroisoquinoline proved to be a highly diastereo-selective processes, resulting in the cis isomers as the main or the only products. (c) 2006 Elsevier Ltd. All rights reserved.
Terjedelem/Fizikai jellemzők:3881-3883
ISSN:0040-4039