Carboxylated magnetic nanoparticles as MRI contrast agents Relaxation measurements at different field strengths /

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Bibliographic Details
Main Authors: Jedlovszky-Hajdú Angéla
Csákiné Tombácz Etelka
Bányai István
Babos Magor
Palkó András
Format: Article
Published: 2012
Series:JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 324 No. 19
Subjects:
AAA
Online access:http://publicatio.bibl.u-szeged.hu/22629
DOI:10.1016/j.jmmm.2012.05.031
MTMT:2001067
Description
Summary:At the moment the biomedical applications of magnetic fluids are the subject of intensive scientific interest. In the present work, magnetite nanoparticles (MNPs) were synthesized and stabilized in aqueous medium with different carboxylic compounds (citric acid (CA), polyacrylic acid (PAA), and sodium oleate (NaOA)), in order to prepare well stabilized magnetic fluids (MFs). The magnetic nanoparticles can be used in the magnetic resonance imaging (MRI) as contrast agents. Magnetic resonance relaxation measurements of the above MFs were performed at different field strengths (i.e., 0.47, 1.5 and 9.4 T) to reveal the field strength dependence of their magnetic responses, and to compare them with that of ferucarbotran, a well-known superparamagnetic contrast agent. The measurements showed characteristic differences between the tested magnetic fluids stabilized by carboxylic compounds and ferucarbotran. It is worthy of note that our magnetic fluids have the highest r2 relaxivities at the field strength of 1.5 T, where the most of the MRI works in worldwide.
Physical Description:3173-3180
ISSN:0304-8853