The psoriatic non-lesional skin a battlefield of constant fight between susceptibility and protective factors /

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Bibliographic Details
Main Authors: Kelemen Evelyn
Bozó Renáta
Groma Gergely
Csörgő Sándorné Bata Zsuzsanna
Kemény Lajos
Danis Judit
Széll Márta
Format: Article
Published: 2021
Series:JOURNAL OF INVESTIGATIVE DERMATOLOGY
Subjects:
AAA
Online access:http://publicatio.bibl.u-szeged.hu/22516
DOI:10.1016/j.jid.2021.05.020
MTMT:32107897
Description
Summary:In the last two decades, large-scale gene-expression studies on psoriatic skin samples revealed that even though non-lesional skin is macroscopically identical to healthy skin, it harbors several molecular differences. Originally, these molecular differences were thought to represent susceptibility factors for plaque formation. However, we review here several factors of immune regulation and structural alteration that are specific for the non-lesional skin and serve as protective factors by counteracting plaque formation and contributing to the maintenance of the non-lesional phenotype.
ISSN:0022-202X