Phenotypic plasticity of melanocytes derived from human adult skin
We previously described a novel in vitro culture technique for dedifferentiated human adult skin melanocytes. Melanocytes cultured in a defined, cholera toxin and PMA free medium became bipolar, unpigmented, and highly proliferative. Furthermore, TRP-1 and c-Kit expression disappeared and EGFR recep...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2022
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| Sorozat: | PIGMENT CELL & MELANOMA RESEARCH
35 No. 1 |
| Tárgyszavak: | |
| doi: | 10.1111/pcmr.13012 |
| mtmt: | 32173395 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/22315 |
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| 024 | 7 | |a 32173395 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Vidács Dániel László | |
| 245 | 1 | 0 | |a Phenotypic plasticity of melanocytes derived from human adult skin |h [elektronikus dokumentum] / |c Vidács Dániel László |
| 260 | |c 2022 | ||
| 300 | |a 38-51 | ||
| 490 | 0 | |a PIGMENT CELL & MELANOMA RESEARCH |v 35 No. 1 | |
| 520 | 3 | |a We previously described a novel in vitro culture technique for dedifferentiated human adult skin melanocytes. Melanocytes cultured in a defined, cholera toxin and PMA free medium became bipolar, unpigmented, and highly proliferative. Furthermore, TRP-1 and c-Kit expression disappeared and EGFR receptor and nestin expression were induced in the cells. Here, we further characterized the phenotype of these dedifferentiated cells and by comparing them to mature pigmented melanocytes we detected crucial steps in their phenotype change. Our data suggest that normal adult melanocytes easily dedifferentiate into pluripotent stem cells given the right environment. This dedifferentiation process described here for normal melanocyte is very similar to what has been described for melanoma cells, indicating that phenotype switching driven by environmental factors is a general characteristic of melanocytes that can occur independent of malignant transformation. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Veréb Zoltán |e aut |
| 700 | 0 | 1 | |a Bozó Renáta |e aut |
| 700 | 0 | 1 | |a Flink Lili Borbála |e aut |
| 700 | 0 | 1 | |a Polyánka Hilda |e aut |
| 700 | 0 | 1 | |a Németh István Balázs |e aut |
| 700 | 0 | 1 | |a Póliska Szilárd |e aut |
| 700 | 0 | 1 | |a Papp Benjamin Tamás |e aut |
| 700 | 0 | 1 | |a Gáspár Róbert |e aut |
| 700 | 0 | 1 | |a Mirdamadi Seyedmohsen |e aut |
| 700 | 0 | 1 | |a Manczinger Máté |e aut |
| 700 | 0 | 1 | |a Kemény Lajos |e aut |
| 700 | 0 | 2 | |a Csörgő Sándorné Bata Zsuzsanna |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/22315/1/pcmr.13012.pdf |z Dokumentum-elérés |