Hypertriglyceridemia-induced acute pancreatitis A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases /

Background Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). It has been shown that hypertriglyceridemia aggravates the severity and related complications of AP; however, detailed analyses of large cohorts are inadequate and contradictory. Our aim was to investigate the...

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Elmentve itt :
Bibliográfiai részletek
Szerzők: Mosztbacher Dóra
Hanák Lilla
Borbásné Farkas Kornélia
Szentesi Andrea Ildikó
Mikó Alexandra
Bajor Judit
Sarlós Patrícia
Czimmer József
Vincze Áron
Hegyi Péter Jenő
Erőss Bálint Mihály
Takács Tamás
Czakó László
Németh Balázs
Szabó-Halász Adrienn
Papp Mária
Illés Dóra
Gódi Szilárd
Kui Balázs
Márta Katalin
Pécsi Dániel
Varjú Péter
Szakács Zsolt
Párniczky Andrea
Hegyi Péter
Dokumentumtípus: Cikk
Megjelent: 2020
Sorozat:PANCREATOLOGY 20 No. 4
doi:10.1016/j.pan.2020.03.018

mtmt:31280739
Online Access:http://publicatio.bibl.u-szeged.hu/21990
Leíró adatok
Tartalmi kivonat:Background Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). It has been shown that hypertriglyceridemia aggravates the severity and related complications of AP; however, detailed analyses of large cohorts are inadequate and contradictory. Our aim was to investigate the dose-dependent effect of hypertriglyceridemia on AP. Methods AP patients over 18 years old who underwent triglyceride measurement within the initial three days were included into our cohort analysis from a prospective international, multicenter AP registry operated by the Hungarian Pancreatic Study Group. Data on 716 AP cases were analyzed. Six groups were created based on the highest triglyceride level (<1.7 mmol/l, 1.7–2.19 mmol/l, 2.2–5.59 mmol/l, 5.6–11.29 mmol/l, 11.3–22.59 mmol/l, ≥22.6 mmol/l). Results Hypertriglyceridemia (≥1.7 mmol/l) presented in 30.6% of the patients and was significantly and dose-dependently associated with younger age and male gender. In 7.7% of AP cases, hypertriglyceridemia (≥11.3 mmol/l) was considered as a causative etiological factor; however, 43.6% of these cases were associated with other etiologies (alcohol and biliary). Hypertriglyceridemia was significantly and dose-dependently related to obesity and diabetes. The rates of local complications, organ failure and maximum CRP level were significantly and dose-dependently raised by hypertriglyceridemia. Triglyceride above 11.3 mmol/l was linked to a significantly higher incidence of moderately severe AP and longer hospital stay, whereas triglyceride over 22.6 mmol/l was significantly associated with severe AP as well. Conclusion Hypertriglyceridemia dose-dependently aggravates the severity and related complications of AP. Diagnostic workup for hypertriglyceridemia requires better awareness regardless of the etiology of AP.
Terjedelem/Fizikai jellemzők:608-616
ISSN:1424-3903