Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are in...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Corradi Chiara
Manuel Gentiluomo
Gajdán László
Cavestro Giulia Martina
Kreivenaite Edita
Di Franco Gregorio
Sperti Cosimo
Giaccherini Matteo
Petrone Maria Chiara
Tavano Francesca
Gioffreda Dmenica
Morelli Luca
Soucek Pavel
Hegyi Péter
Szentesi Andrea Ildikó
Dokumentumtípus: Cikk
Megjelent: 2021
Sorozat:INTERNATIONAL JOURNAL OF CANCER 148 No. 11
doi:10.1002/ijc.33475

mtmt:31849971
Online Access:http://publicatio.bibl.u-szeged.hu/21968
Leíró adatok
Tartalmi kivonat:Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability has been unexplored so far. Combining genome wide association studies and functional data, we investigated the genetic variability in all lncRNAs. We analyzed 9893 PDAC cases and 9969 controls and identified a genome-wide significant association between the rs7046076 SNP and risk of developing PDAC (P = 9.73 × 10-9 ). This SNP is located in the NONHSAG053086.2 (lnc-SMC2-1) gene and the risk allele is predicted to disrupt the binding of the lncRNA with the micro-RNA (miRNA) hsa-mir-1256 that regulates several genes involved in cell cycle, such as CDKN2B. The CDKN2B region is pleiotropic and its genetic variants have been associated with several human diseases, possibly though an imperfect interaction between lncRNA and miRNA. We present a novel PDAC risk locus, supported by a genome-wide statistical significance and a plausible biological mechanism.
Terjedelem/Fizikai jellemzők:2779-2788
ISSN:0020-7136