γ-Aminobutyric Acid and Derivatives Reduce the Incidence of Acute Pain after Herpes Zoster- A Systematic Review and Meta-analysis

Herpes zoster (HZ) causes considerable pain and distress, and γ-Aminobutyric acid (GABA) and its derivatives are assumed to control this, but the available data are inconsistent. This metaanalysis and systematic review aimed to assess the effectiveness of GABA derivatives in the prevention of acute...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Wuttapon Sadaeng
Márta Katalin
Mátrai Péter
Hegyi Péter
Tóth Barbara
Németh Balázs
Czumbel László Márk
Sang-Ngoen Thanyaporn
Gyöngyi Zoltán
Varga Gábor
Révész Péter
Szanyi István
Karádi Kázmér
Gerber Gábor
Dokumentumtípus: Cikk
Megjelent: 2020
Sorozat:CURRENT PHARMACEUTICAL DESIGN 26 No. 25
doi:10.2174/1381612826666200605120242

mtmt:31336803
Online Access:http://publicatio.bibl.u-szeged.hu/21194
Leíró adatok
Tartalmi kivonat:Herpes zoster (HZ) causes considerable pain and distress, and γ-Aminobutyric acid (GABA) and its derivatives are assumed to control this, but the available data are inconsistent. This metaanalysis and systematic review aimed to assess the effectiveness of GABA derivatives in the prevention of acute herpetic pain. The meta-analysis was conducted following the PRISMA guidelines using PICO format, registered in PROSPERO number CRD42018095758. PubMed, Web of Science, Ovid, Scopus, and EMBASE databases were searched. Records were included if they were randomized controlled trials of patients undergoing HZ infection, investigating the effect of GABA derivatives versus placebo in the treatment of HZ pain. Eligible trials were evaluated for the risk of bias. Then data were extracted and analysed. The number of patients with observed presence of pain after treatment was used to calculate odds ratio in a random effect model with the DerSimonian-Laird estimator. The I 2 statistic was analysed for heterogeneity. The potential risk of bias was measured using Egger's regression test. The metaanalysis included three randomized controlled trials with a total of 297 patients. The incidence of acute HZ pain events for GABA group was significantly lower compared to placebo group,18/148 vs 44/159, respectively (OR = 0.36; 95% CI = 0.14 to 0.93; Z = 2.11; P = 0.035), Egger's test yielded P = 0.308. In conclusion, the present meta-analysis demonstrates that GABA derivatives reduce the incidence of acute herpetic pain. However, additional, well-designed randomized clinical trials are needed to determine their dose- and time-dependency regarding this symptom.
Terjedelem/Fizikai jellemzők:3026-3038
ISSN:1381-6128