Could basement membrane alterations, resembling micro-wounds at the dermo-epidermal junction in psoriatic non-lesional skin, make the skin susceptible to lesion formation?

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Bibliographic Details
Main Authors: Bozó Renáta
Flink Lili Borbála
Belső Nóra
Konczné Gubán Barbara
Széll Márta
Kemény Lajos
Csörgő Sándorné Bata Zsuzsanna
Format: Article
Published: 2020
Series:EXPERIMENTAL DERMATOLOGY 30 No. 6
AAA
Online access:http://publicatio.bibl.u-szeged.hu/20278
DOI:10.1111/exd.14267
MTMT:31798342
Description
Summary:Current data suggest that tissue microenvironment control immune functions. Therefore, understanding the tissue environment in which immune activation occurs will enhance our capability to interfere with abnormal immune pathology. Here, we argue that studying the constitutively abnormal functions of clinically uninvolved psoriatic skin in patients with plaque type psoriasis is very important to better understand psoriasis pathobiology, because non-lesional skin provides the tissue environment in which the psoriatic lesion develops. A key question in psoriasis is what initiates the abnormal, uncontrolled immune activation in the first place and the answer may lie in the skin. In light of this concept, we summarize abnormalities at the dermal-epidermal junction region which shows a special "nonhealing-like" micro-wound phenotype in the psoriatic non-lesional skin that may act as a crucial susceptibility factor in the development of the disease.
Physical Description:765-772
ISSN:0906-6705