Critical thresholds key to unlocking the door to the prevention and specific treatments for acute pancreatitis /

Acute pancreatitis (AP), an acute inflammatory disorder of the exocrine pancreas, is one of the most common gastrointestinal diseases encountered in emergency departments with no specific treatments. Laboratory-based research has formed the cornerstone of endeavours to decipher the pathophysiology o...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Barreto Savio George
Habtezion Aida
Gukovskaya Anna
Lugea Aurelia
Jeon Christie
Yadav Dhiraj
Hegyi Péter
Venglovecz Viktória
Sutton Robert
Pandol Stephen J.
Dokumentumtípus: Cikk
Megjelent: 2020
Sorozat:GUT
doi:10.1136/gutjnl-2020-322163

mtmt:31611592
Online Access:http://publicatio.bibl.u-szeged.hu/19753
Leíró adatok
Tartalmi kivonat:Acute pancreatitis (AP), an acute inflammatory disorder of the exocrine pancreas, is one of the most common gastrointestinal diseases encountered in emergency departments with no specific treatments. Laboratory-based research has formed the cornerstone of endeavours to decipher the pathophysiology of AP, because of the limitations of such study in human beings. While this has provided us with substantial understanding, we cannot answer several pressing questions. These are: (a) Why is it that only a minority of individuals with gallstones, or who drink alcohol excessively, or are exposed to other causative factors develop AP? (b) Why do only some develop more severe manifestations of AP with necrosis and/or organ failure? (c) Why have we been unable to find an effective therapeutic for AP? This manuscript provides a state-of-the-art review of our current understanding of the pathophysiology of AP providing insights into the unanswered clinical questions. We describe multiple protective factors operating in most people, and multiple stressors that in a minority induce AP, independently or together, via amplification loops. We present testable hypotheses aimed at halting progression of severity for the development of effective treatments for this common unpredictable disease.
ISSN:0017-5749