HLA-DR genotypes in familial rheumatoid arthritis increased frequency of protective and neutral alleles in a multicase family /

OBJECTIVE: We describe a unique family where each of the 5 siblings in the second generation has rheumatoid arthritis (RA). Two other members of the family have RA and systemic lupus erythematosus (SLE), respectively. No members of previous generations in the family had documented inflammatory arthr...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Zsilak Szilvia
Gál János
Hodinka László
Rajczy Katalin
Balog Attila
Sipka Sándor
Baráth Sándor
Kapitány Anikó
Zilahi Erika
Szekanecz Zoltán
Dokumentumtípus: Cikk
Megjelent: 2005
Sorozat:JOURNAL OF RHEUMATOLOGY 32 No. 12
mtmt:1320916
Online Access:http://publicatio.bibl.u-szeged.hu/19535
Leíró adatok
Tartalmi kivonat:OBJECTIVE: We describe a unique family where each of the 5 siblings in the second generation has rheumatoid arthritis (RA). Two other members of the family have RA and systemic lupus erythematosus (SLE), respectively. No members of previous generations in the family had documented inflammatory arthritis. Due to the suspected genetic predisposition, HLA-DR genotypes were determined in the affected siblings and their parents, children, and grandchildren. We investigated the possible role of various HLA-DR alleles in the evolution of RA in this multicase family. METHODS: HLA-DRB1* alleles were determined by polymerase chain reaction using the sequence-specific primer-Olerup method. RESULTS: The most common alleles in the 6 persons with RA were HLA-DRB1*07 and DRB1*15, which are known to be protective and neutral in RA. No patient or family member carried any HLA-DR4 alleles. CONCLUSION: HLA-DRB1*07 and DRB1*15 alleles are thought to be protective or neutral in RA. However, the majority of RA patients in the family and nearly half of all family members carried these alleles, suggesting a role of these genotypes in susceptibility to RA. No RA patient in this family carried HLA-DR4 alleles. Thus, in our rare family with 6 RA cases, an unexpected genetic background may be involved in the increased susceptibility to inflammatory arthritis.
Terjedelem/Fizikai jellemzők:2299-2302
ISSN:0315-162X