Liver-on-a-Chip‒Magnetic nanoparticle bound synthetic metalloporphyrin-catalyzed biomimetic oxidation of a drug in a magnechip reactor
Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20‐tetrakis‐(4‐sulfonatophenyl)...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2019
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| Sorozat: | MICROMACHINES
10 No. 10 |
| doi: | 10.3390/mi10100668 |
| mtmt: | 30819660 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/18860 |
| Tartalmi kivonat: | Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites. The immobilization of 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin (FeTPFP) and 5,10,15,20‐tetrakis‐(4‐sulfonatophenyl)iron(II) porphyrin (FeTSPP) via stable covalent or rapid ionic binding on aminopropyl-functionalized magnetic nanoparticles (MNPs-NH2) were developed. These immobilized catalysts could be efficiently applied for the synthesis of new pharmaceutically active derivatives and liver related phase I oxidative major metabolite of an antiarrhythmic drug, amiodarone integrated in a continuous-flow magnetic chip reactor (Magnechip). |
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| Terjedelem/Fizikai jellemzők: | Azonosító: 668-Terjedelem: 13 p |
| ISSN: | 2072-666X |