Acral lentiginous melanoma a single-centre retrospective review of four decades in East-Central Europe /
Acral lentiginous melanoma (ALM) occurs on the palms, soles, and subungual surface and has poor prognosis. It is uncommon in the Caucasian population and has remained unreported in East-Central Europe.Our aim was to collect data from East-Central Europe by analyzing the demographic and clinicopathol...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2020
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| Sorozat: | JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
34 No. 9 |
| doi: | 10.1111/jdv.16227 |
| mtmt: | 31181068 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/18533 |
| Tartalmi kivonat: | Acral lentiginous melanoma (ALM) occurs on the palms, soles, and subungual surface and has poor prognosis. It is uncommon in the Caucasian population and has remained unreported in East-Central Europe.Our aim was to collect data from East-Central Europe by analyzing the demographic and clinicopathologic features of patients with ALM and comparing data with the reports in literature.We conducted a single-center, retrospective review between 1976 and 2016 at one of the largest melanoma referral centers in Hungary.We identified 176 patients with ALM (3.83%) from 4593 patients with melanoma (mean age: 66.2 years). The tumors were mainly located on the lower extremities (88.63%). The mean Breslow tumor thickness was 3.861 mm, 37.50% of the tumors were thicker than 4.00 mm, and 71.6% exhibited microscopic ulceration. Nearly one-third of the patients underwent sentinel lymph node (SLN) biopsy, and 60.3% of the biopsies were positive for metastasis. The positive SLN status was associated with significantly thick tumors and reduced survival. Patients with ALM had 5- and 10-year overall survival rates of 60.5% and 41.6%, respectively. The mean delay in diagnosis was 18 months after the discovery of skin tumors. In multivariate analyses, age, tumor thickness, and distant metastasis were independent risk factors for poor survival (p < 0.001).Our study, which is the first single-center report in East-Central Europe focusing on ALM, confirms that patient and tumor characteristics and prognostic factors are similar with previous literature data involving Caucasians; however, tumor thickness and survival suggest even worse prognosis. |
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| Terjedelem/Fizikai jellemzők: | 2004-2010 |
| ISSN: | 0926-9959 |