Furocoumarin Content of Fennel - Below the Safety Threshold
Furocoumarins are known for their phototoxic and potential carcinogenic effects. These types of compounds have previously been reported from fennel (Foeniculum vulgare Mill.), a widely used medicinal plant and spice; however, no reliable quantitative data are available on the occurrence of these com...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
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2019
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| Sorozat: | MOLECULES
24 No. 15 |
| doi: | 10.3390/molecules24152844 |
| mtmt: | 30758620 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/16389 |
| Tartalmi kivonat: | Furocoumarins are known for their phototoxic and potential carcinogenic effects. These types of compounds have previously been reported from fennel (Foeniculum vulgare Mill.), a widely used medicinal plant and spice; however, no reliable quantitative data are available on the occurrence of these compounds in fennel fruits. For the first time, we report a comprehensive analysis of fennel fruit samples of different origins, representing a wide range of accessions for their furocoumarin content. Psoralene, 5-methoxypsoralene (bergapten), and imperatorin contents of 33 fennel samples were analyzed using a sensitive liquid chromatography-mass spectrometry (LC-MS) method. When applied at the highest therapeutic dose described in the monograph issued by the European Medicines Agency, the furocoumarin content of the fruits ranged up to 1.22 μg/d, which is below the most restrictive recommendations. Based on our findings, fennel consumption can be considered as safe, at least based on its low furocoumarin content. |
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| Terjedelem/Fizikai jellemzők: | Paper 2844-7 p |
| ISSN: | 1420-3049 |