Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone
Half-sandwich organometallic complexes of curcumin are extensively investigated as anticancer compounds. Speciation studies were performed to explore the solution stability of curcumin complexes formed with [Rh(η 5 -C 5 Me 5 )(H 2 O) 3 ] 2+ . Acetylacetone (Hacac), as the simplest β-diketone ligand...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2019
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| Sorozat: | JOURNAL OF INORGANIC BIOCHEMISTRY
195 |
| doi: | 10.1016/j.jinorgbio.2019.02.015 |
| mtmt: | 30483477 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/16016 |
| Tartalmi kivonat: | Half-sandwich organometallic complexes of curcumin are extensively investigated as anticancer compounds. Speciation studies were performed to explore the solution stability of curcumin complexes formed with [Rh(η 5 -C 5 Me 5 )(H 2 O) 3 ] 2+ . Acetylacetone (Hacac), as the simplest β-diketone ligand bearing (O,O) donor set, was involved for comparison and its Ru(η 6 ‑p‑cymene), Ru(η 6 ‑toluene) complexes were also studied. 1 H NMR, UV–visible and pH-potentiometric titrations revealed a clear trend of stability constants of the acac complexes: Ru(η 6 ‑p‑cymene) > Ru(η 6 ‑toluene) > Rh(η 5 -C 5 Me 5 ). Despite this order, the highest extent of complex formation is seen for the Rh(η 5 -C 5 Me 5 ) complexes at pH 7.4. Formation constant of [Rh(η 5 -C 5 Me 5 )(H 2 curcumin)(H 2 O)] + reveals similar solution stability to that of the acac complex. Additionally, structures of two complexes were determined by X-ray crystallography. The in vitro cytotoxicity of curcumin was not improved by the complexation with these organometallic cations. © 2019 |
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| Terjedelem/Fizikai jellemzők: | 91-100 |
| ISSN: | 0162-0134 |