Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β42 monomer

A series of novel mimetic peptides were designed, synthesised and biologically evaluated as inhibitors of Aβ42 aggregation. One of the synthesised peptidic compounds, termed compound 7 modulated Aβ42 aggregation as demonstrated by thioflavin T fluorescence, acting also as an inhibitor of the cytotox...

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Bibliographic Details
Main Authors: Gera János
Szögi Titanilla
Bozsó Zsolt
Fülöp Lívia
Barrera Exequiel E.
Rodriguez Ana M.
Méndez Luciana
Delpiccolo Carina M.L
Mata Ernesto G.
Cioffi Federica
Broersen Kerensa
Paragi Gábor
Enriz Ricardo D.
Format: Article
Published: 2018
Series:BIOORGANIC CHEMISTRY 81
doi:10.1016/j.bioorg.2018.08.018

mtmt:3405755
Online Access:http://publicatio.bibl.u-szeged.hu/14901

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