Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β42 monomer

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Bibliographic Details
Main Authors: Gera János
Szögi Titanilla
Bozsó Zsolt
Fülöp Lívia
Barrera Exequiel E.
Rodriguez Ana M.
Méndez Luciana
Delpiccolo Carina M.L.
Mata Ernesto G.
Cioffi Federica
Broersen Kerensa
Paragi Gábor
Enriz Ricardo D.
Format: Article
Published: 2018
Series:BIOORGANIC CHEMISTRY 81
AAA
Online access:http://publicatio.bibl.u-szeged.hu/14901
DOI:10.1016/j.bioorg.2018.08.018
MTMT:3405755
Description
Summary:A series of novel mimetic peptides were designed, synthesised and biologically evaluated as inhibitors of Aβ42 aggregation. One of the synthesised peptidic compounds, termed compound 7 modulated Aβ42 aggregation as demonstrated by thioflavin T fluorescence, acting also as an inhibitor of the cytotoxicity exerted by Aβ42 aggregates. The early stage interaction between compound 7 and the Aβ42 monomer was investigated by replica exchange molecular dynamics (REMD) simulations and docking studies. Our theoretical results revealed that compound 7 can elongate the helical conformation state of an early stage Aβ42 monomer and it helps preventing the formation of β-sheet structures by interacting with key residues in the central hydrophobic cluster (CHC). This strategy where early “on-pathway” events are monitored by small molecules will help the development of new therapeutic strategies for Alzheimer’s disease.
Physical Description:211-221
ISSN:0045-2068