Diabetes mellitus endotheldiszfunkcio es haemostasiselvaltozasok /
Diabetes mellitus involves a group of chronic metabolic disorders with elevated blood glucose concentrations. Since this disease needs lifelong treatment and care, the medical and social aspects present major public health concerns and pose a global challenge for health care providers. The numbe...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2018
|
| Sorozat: | ORVOSI HETILAP
159 No. 33 |
| doi: | 10.1556/650.2018.31130 |
| mtmt: | 3421457 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/14120 |
| LEADER | 02671nab a2200277 i 4500 | ||
|---|---|---|---|
| 001 | publ14120 | ||
| 005 | 20181203125546.0 | ||
| 008 | 181203s2018 hu o 0|| magyar d | ||
| 022 | |a 0030-6002 | ||
| 024 | 7 | |a 10.1556/650.2018.31130 |2 doi | |
| 024 | 7 | |a 3421457 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a magyar | ||
| 100 | 1 | |a Babik Barna | |
| 245 | 1 | 0 | |a Diabetes mellitus |h [elektronikus dokumentum] : |b endotheldiszfunkcio es haemostasiselvaltozasok / |c Babik Barna |
| 260 | |c 2018 | ||
| 300 | |a 1335-1345 | ||
| 490 | 0 | |a ORVOSI HETILAP |v 159 No. 33 | |
| 520 | 3 | |a Diabetes mellitus involves a group of chronic metabolic disorders with elevated blood glucose concentrations. Since this disease needs lifelong treatment and care, the medical and social aspects present major public health concerns and pose a global challenge for health care providers. The number of aged patients with degenerative diseases undergoing surgical procedures is continuously increasing, resulting in an overwhelming dominance of diabetes in the perioperative care. There is a particular need for an increased awareness of diabetic patients in cardiovascular units, where the incidence of this disease reaches as high as 30-40%. The main hallmarks of the pathologic metabolic milieu of diabetes are hyperglycaemia, insulin resistance and pathologic lipid metabolism. The biochemical, cellular and organ-level pathophysiological changes lead to endothelial dysfunction including a low-grade prothrombotic balance, inflammatory state and, as a consequence, impaired micro- and macrocirculation. Diabetes is also followed by platelet dysfunction resulting from intracellular hyperglycaemia, because thrombocytes have insulin-independent glucose transporters in their cell membrane. The levels of the coagulation factors of the plasma are increased, and these factors are also modified by oxidation and glycation. Diabetes mellitus is a prothrombotic condition resulting from direct and indirect tendencies of the endothelial platelet and the plasma coagulation factors. The basic "bench to clinical basics" knowledge of the endothelial dysfunction and prothrombotic balance in diabetes may contribute to the better understanding of the clinical focuses in the perioperative care of patients with diabetes mellitus. Orv Hetil. 2018; 159(33): 1335-1345. | |
| 700 | 0 | 1 | |a Peták Ferenc |e aut |
| 700 | 0 | 1 | |a Agócs Szilvia |e aut |
| 700 | 0 | 1 | |a Blaskovics Ivett |e aut |
| 700 | 0 | 1 | |a Alács Endre |e aut |
| 700 | 0 | 1 | |a Bodó Kinga |e aut |
| 700 | 0 | 1 | |a Südy Roberta |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/14120/1/650.2018.31130.pdf |z Dokumentum-elérés |