Decreased cutaneous vasodilatation to isometric handgrip exercise in Alzheimer's disease
Background Cutaneous active vasodilatation is a cholinergic nerve mediated function of the sympathetic nervous system and the disturbed function of cholinergic neurotransmission is known as a prominent feature of Alzheimer's disease (AD). Methods To assess this relationship, skin blood flow (S...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2002
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| Sorozat: | INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
17 No. 4 |
| doi: | 10.1002/gps.609 |
| mtmt: | 1131834 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/14092 |
| Tartalmi kivonat: | Background Cutaneous active vasodilatation is a cholinergic nerve mediated function of the sympathetic nervous system and the disturbed function of cholinergic neurotransmission is known as a prominent feature of Alzheimer's disease (AD). Methods To assess this relationship, skin blood flow (SkBF) and other haemodynamic parameters were determined by a simple vasodilatory test, isometric handgrip exercise (IHG), in 22 late-onset sporadic type AD and 20 aged control persons (AC). Results Significantly higher cutaneous vascular resistance and decreased SkBF were found after the stimulus in the AD group. A smaller reduction (p < 0.03) of R wave intervals on the electrocardiogram was observed in the AD group compared to the AC one. After IHG, change in systolic blood pressure was less in the AD (p < 0.01) than in the AC group. Conclusion Our results suggest that autonomic dysfunction affecting active vasodilator sympathetic, as well as parasympathetic functions is present in AD. |
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| Terjedelem/Fizikai jellemzők: | 371-374 |
| ISSN: | 0885-6230 |