Pharmacokinetics of selegiline in a rabbit model
Background: Selegiline is one of the most widely used monoamine oxidase B inhibitors for the treatment of Parkinson’s disease in early stage. Objective: Time-dependent distribution of selegiline was monitored in various tissues of rabbits treated with a dose of 30 mg/kg intravenously. Method: Selegi...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2016
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| Sorozat: | LETTERS IN DRUG DESIGN AND DISCOVERY
13 No. 8 |
| doi: | 10.2174/1570180813666160125224604 |
| mtmt: | 3024843 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/13908 |
| Tartalmi kivonat: | Background: Selegiline is one of the most widely used monoamine oxidase B inhibitors for the treatment of Parkinson’s disease in early stage. Objective: Time-dependent distribution of selegiline was monitored in various tissues of rabbits treated with a dose of 30 mg/kg intravenously. Method: Selegiline content was determined by validated HPLC method following 5,15, 30, 60 and 120 minutes of treatment. Results: A time-dependent decline of selegiline tissue levels was observed in the iris, the cornea and the intraocular lens, while the maximum level of selegiline in the serum, in the brain, in the testis and in the retina was found at 15 min following administration. |
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| Terjedelem/Fizikai jellemzők: | 752-756 |
| ISSN: | 1570-1808 |