Characterization of a proteolytically stable d-Peptide that suppresses herpes simplex virus 1 infection implications for the development of entry-based antiviral therapy /
Uncontrolled herpes simplex virus 1 (HSV-1) infection can advance to serious conditions, including corneal blindness or fatal encephalitis. Here, we describe a highly potent anti-HSV-1 peptide (DG2) that inhibits HSV-1 entry into host cells and blocks all aspects of infection. Importantly, DG2 is h...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
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American Society for Microbiology
2015
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| Sorozat: | JOURNAL OF VIROLOGY
89 No. 3 |
| doi: | 10.1128/JVI.02979-14 |
| mtmt: | 2849983 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/13505 |
| Tartalmi kivonat: | Uncontrolled herpes simplex virus 1 (HSV-1) infection can advance to serious conditions, including corneal blindness or fatal encephalitis. Here, we describe a highly potent anti-HSV-1 peptide (DG2) that inhibits HSV-1 entry into host cells and blocks all aspects of infection. Importantly, DG2 is highly resistant to proteases and shows minimal toxicity, paving the way for prophylactic or therapeutic application of the peptide in vivo. |
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| Terjedelem/Fizikai jellemzők: | 1932-1938 |
| ISSN: | 0022-538X |