Solid-phase synthesis of 6,7-cycloalkane-fused 1,4-diazepane-2,5-diones via a cyclization/release strategy
A solid-phase synthesis procedure for the parallel preparation of 6,7-cycloalkane-fused 1,4-diazepane-2,5-diones is described. The methodology applies alpha- and alicyclic beta-amino acid building blocks to construct the seven-membered heterocyclic core, while alcohols are used for further skeletal...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
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2016
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| Sorozat: | TETRAHEDRON
72 No. 1 |
| doi: | 10.1016/j.tet.2015.11.023 |
| mtmt: | 3005721 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/12634 |
| Tartalmi kivonat: | A solid-phase synthesis procedure for the parallel preparation of 6,7-cycloalkane-fused 1,4-diazepane-2,5-diones is described. The methodology applies alpha- and alicyclic beta-amino acid building blocks to construct the seven-membered heterocyclic core, while alcohols are used for further skeletal decoration. The use of a cyclization/release strategy permits the isolation of the target cyclic alpha,beta-dipeptides in good crude purities and generally moderate to good yields. A 26-membered model library is reported and NMR spectroscopical data are used to describe the overall conformational behaviour of the obtained homodiketopiperazines. (C) 2015 Elsevier Ltd. All rights reserved. |
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| Terjedelem/Fizikai jellemzők: | 148-160 |
| ISSN: | 0040-4020 |