The proteomic profile of a mouse model of proliferative vitreoretinopathy
Proliferative vitreoretinopathy (PVR) develops as a complication of retinal detachment surgery and represents a devastating condition leading to serious vision loss. A good animal model that permits extensive functional studies and drug testing is crucial in finding better therapeutic modalities for...
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| Dokumentumtípus: | Cikk |
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Elsevier
2017
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| Sorozat: | FEBS OPEN BIO
7 No. 8 |
| doi: | 10.1002/2211-5463.12252 |
| mtmt: | 3255497 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/12222 |
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| 024 | 7 | |a 3255497 |2 mtmt | |
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| 041 | |a zxx | ||
| 100 | 1 | |a Márkus Bernadett | |
| 245 | 1 | 4 | |a The proteomic profile of a mouse model of proliferative vitreoretinopathy |h [elektronikus dokumentum] / |c Márkus Bernadett |
| 260 | |a Elsevier |c 2017 | ||
| 300 | |a 1166-1177 | ||
| 490 | 0 | |a FEBS OPEN BIO |v 7 No. 8 | |
| 520 | 3 | |a Proliferative vitreoretinopathy (PVR) develops as a complication of retinal detachment surgery and represents a devastating condition leading to serious vision loss. A good animal model that permits extensive functional studies and drug testing is crucial in finding better therapeutic modalities for PVR. A previously established mouse model, using dispase injection, was analyzed from the proteomic point of view, examining global protein profile changes by 2D electrophoresis, image analysis and HPLC-tandem mass spectrometry-based protein identification. The easy applicability of the mouse model was used to study the role of transglutaminase 2 (TG2) in PVR formation by proteomic examination of dispase-induced TG2 knockout vitreous samples. Our data demonstrate that, despite the altered appearance of crystallin proteins, the lack of TG2 did not prevent the development of PVR. | |
| 700 | 0 | 1 | |a Pató Zsuzsanna |e aut |
| 700 | 0 | 1 | |a Sarang Zsolt |e aut |
| 700 | 0 | 1 | |a Albert Réka |e aut |
| 700 | 0 | 1 | |a Tőzsér József |e aut |
| 700 | 0 | 1 | |a Petrovski Goran |e aut |
| 700 | 0 | 1 | |a Csősz Éva |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/12222/1/The_proteomic_prole_of_a_mouse_model_of_proliferative_vitreoretinopathy__u.pdf |z Dokumentum-elérés |