Interactions between the kynurenine and the endocannabinoid system with special emphasis on migraine

Both the kynurenine and the endocannabinoid systems are involved in several neurological disorders, such as migraine and there are increasing number of reports demonstrating that there are interactions of two systems. Although their cooperation has not yet been implicated in migraine, there are repo...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Nagy-Grócz Gábor
Zádor Ferenc
Dvorácskó Szabolcs
Bohár Zsuzsanna
Benyhe Sándor
Tömböly Csaba
Párdutz Árpád
Vécsei László
Dokumentumtípus: Cikk
Megjelent: MDPI AG 2017
Sorozat:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18 No. 8
Tárgyszavak:
doi:10.3390/ijms18081617

mtmt:3254479
Online Access:http://publicatio.bibl.u-szeged.hu/12143
Leíró adatok
Tartalmi kivonat:Both the kynurenine and the endocannabinoid systems are involved in several neurological disorders, such as migraine and there are increasing number of reports demonstrating that there are interactions of two systems. Although their cooperation has not yet been implicated in migraine, there are reports suggesting this possibility. Additionally, the individual role of the endocannabinoid and kynurenine system in migraine is reviewed here first, focusing on endocannabinoids, kynurenine metabolites, in particular kynurenic acid. Finally, the function of NMDA and cannabinoid receptors in the trigeminal system—which has a crucial role in the pathomechanisms of migraine—will also be discussed. The interaction of the endocannabinoid and kynurenine system has been demonstrated to be therapeutically relevant in a number of pathological conditions, such as cannabis addiction, psychosis, schizophrenia and epilepsy. Accordingly, the cross-talk of these two systems may imply potential mechanisms related to migraine, and may offer new approaches to manage the treatment of this neurological disorder. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
Terjedelem/Fizikai jellemzők:Azonosító: 1617-Terjedelem: 22 p.
ISSN:1661-6596