Excitotoxins, mitochondrial and redox disturbances in multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). There is increasing evidence that MS is not only characterized by immune mediated inflammatory reactions, but also by neurodegenerative processes. There is cumulating evidence that neurodegenerative proces...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Rajda Cecília
Pukoli Dániel
Bende Zsuzsanna
Majláth Zsófia
Vécsei László
Dokumentumtípus: Cikk
Megjelent: MDPI AG 2017
Sorozat:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18 No. 2
doi:10.3390/ijms18020353

mtmt:3192890
Online Access:http://publicatio.bibl.u-szeged.hu/11719
Leíró adatok
Tartalmi kivonat:Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). There is increasing evidence that MS is not only characterized by immune mediated inflammatory reactions, but also by neurodegenerative processes. There is cumulating evidence that neurodegenerative processes, for example mitochondrial dysfunction, oxidative stress, and glutamate (Glu) excitotoxicity, seem to play an important role in the pathogenesis of MS. The alteration of mitochondrial homeostasis leads to the formation of excitotoxins and redox disturbances. Mitochondrial dysfunction (energy disposal failure, apoptosis, etc.), redox disturbances (oxidative stress and enhanced reactive oxygen and nitrogen species production), and excitotoxicity (Glu mediated toxicity) may play an important role in the progression of the disease, causing axonal and neuronal damage. This review focuses on the mechanisms of mitochondrial dysfunction (including mitochondrial DNA (mtDNA) defects and mitochondrial structural/functional changes), oxidative stress (including reactive oxygen and nitric species), and excitotoxicity that are involved in MS and also discusses the potential targets and tools for therapeutic approaches in the future. © 2017 by the authors; licensee MDPI, Basel, Switzerland.
Terjedelem/Fizikai jellemzők:Terjedelem: 28 p-Azonosító: 353
ISSN:1661-6596